Protein Details: Small conductance calcium-activated potassium channel protein 2

Protein ID

ICDB_Pro_0641

Protein Name

Small conductance calcium-activated potassium channel protein 2

Gene Name

Kcnn2; Sk2

Organism

Mus musculus (Mouse)

Length

839 amino acids

AlphaFoldDB

AF-P58390-F1-model_v4.pdb

Function

Forms a voltage-independent potassium channel activated by intracellular calcium . Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization

Sequence

MPIVLVRPTNRTRRLDSTGAGMGPSSHQQQESPLPTITHCAGCTTAWSPCSFNSSDMETPLQFQRGFFPEQPPPPPRSSHLHCQQQQQSQDKPCAPFAPLPHPHHHPHLAHQQPGSGGSSPCLRCNSCASSGAPAAGAGAGDNLSLLLRTSSPGGAFRTRTSSPLSGSSCCCCCSSRRGSQLNVSELTPSSHASALRQQYAQQPASASQYHQCHSLQPATSPTGSLGSLGSGPPLSHHHHHPHPAHHQHHQPQARRESNPFTEIAMSSCRYNGGVMRPLSNLSSSRRNLQEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVSYNAERSRSSSRRRRSSSTAPPTSSESS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in atrial and ventricular myocytes with higher levels in atrial myocytes (at protein level). Highly expressed in brain; liver and colon with low levels in kidney and testis. In colon; detected in smooth muscle cells.

DOI ID

10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1152/jn.00630.2003; 10.1101/gr.2596504; 10.1152/ajpgi.2001.281.4.g964; 10.1074/jbc.m307508200; 10.1152/ajpheart.00534.2005; 10.1016/j.cell.2010.12.001; 10.7554/elife.12637

RefSeq

NP_001299834.1; NP_536713.1